Response to DSBs
| PAG Title | Response to DSBs |
| PAG ID | WIG001819 |
| Type | P |
| Source Link |  Spike |
| Publication Reference | NA |
| PAG Description | DNA double-strand breaks (DSBs) arise in cells from and exogenous and endogenous attacks on the DNA backbone. Ionizing radiation (IR)] is the main exogenous cause of DSB. Proper repair of DSBs is critical and essential for maintaining genomic integrity and stability. Eukaryotic organisms have evolved multi-potent and efficient mechanisms to repair DSBs that are primarily divided into two types of pathways: nonhomologous end joining (NHEJ) and homologous recombination (HR). |
| Species | Homo sapiens |
| nCoCo Score | 2,708 |
| Base PAG ID | WIG001819 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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